Promise study shows one quarter of non–invasive cardiac tests may be safely deferred.
A two year follow–up on a study involving more than 10,000 people with stable chest pain finds that an online tool can accurately predict which patients are likely to have normal non–invasive tests and remain free of cardiac events. The study, published in JAMA Cardiology journal, could lead to better decision making by primary care doctors, by helping them identify patients at minimal risk for heart trouble.
“There are millions of stress tests done every year in the United States and many of them are normal,” said James Udelson, MD, Chief of the Division of Cardiology at Tufts Medical Center and the senior investigator on the study. “We thought that if we could predict the outcome of these tests by using information we already had from the patient before the test, we could potentially save the health care system money and save our patients time and worry.”
The analysis used data from a 2015 clinical trial led by researchers at Duke University School of Medicine called the PROMISE trial (Prospective Multicenter Imaging Study for Evaluation of Chest Pain). The study enrolled just over 10,000 patients at 193 sites in North America who had no known Coronary Artery Disease (CAD) but who reported chest pain or equivalent symptoms to their physician and were referred for non–invasive testing to assess for the presence of CAD. Patients were randomized to have either an exercise stress test (often with an imaging study of heart blood flow or function) or a CT scan of the coronary arteries. While the study found both tests to be equally accurate in detecting heart trouble, it determined that approximately 25 percent of patients had completely normal results.
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