Prehospital Epinephrine Associated with Higher ROSC and Lower Long-Term Arrest Survival

From MedPage Today:

For out-of-hospital cardiac arrest, administration of epinephrine on the way to the hospital initially improves the chances of resuscitation but hurts survival and function longer term, Japanese researchers found.

Circulation returned before arrival at the hospital for 18.5% of those given the adrenaline drug intravenously by paramedics, compared with 5.7% who didn’t receive it (P<0.001) in a registry study by Akihito Hagihara, DMSc, MPH, of Kyushu University in Fukuoka, Japan, and colleagues.

However, survival to one month was 54% less likely and survival without severe neurological disability was 68% less likely with prehospital administration of epinephrine, the group reported in the March 21 issue of the Journal of the American Medical Association.